Suction Cup Raman Probe

Suction Cup Raman Probe

IS-Instruments has developed a Raman probe to measure samples through glass, acrylic, and other optical mediums that would typically obscure spectroscopic measurements.

This probe, which uses a biaxial design, was designed to be retrofitted to freeze-dryers to monitor freeze-drying runs through thick acrylic or glass, which traditional Czerny-Turner-based spectrometers often struggle to do.

These probes, designed with a 100 mm focal length, integrate with the ISI range of HES spectrometers, which offer a 100-fold increase in throughput over current conventional systems.

Product Specifications

ISI Suction Cup Raman Probe CutOut

Suction Cup Raman Probe

Using Principal Component Analysis (PCA) with our Raman measurements has shown that it is possible to identify the different stages of freeze-drying, particularly the transitions of mannitol into its various polymorphs.

This allows the user to monitor the freeze-drying process in real time by monitoring the exact crystal structure of the sample.

Raman spectra of paracetamol, mannitol, and polyclonal IgG are shown. All Raman spectra were captured through a 25mm acrylic window and a glass vial (see below).

Applications include:
  • Lyophilisation of pharmaceuticals and therapeutic agents
  • Measuring chemicals inside fume cupboards
  • Mounting to glovebox windows used in the nuclear industry
Feature Detail
Raman operating λ 785 nm
Configuration Biaxial
Standoff distance (from 100mm diameter window) ~ 1000 mm
Laser fibre connection FC/PC
Spectrometer fibre connection SMA
Dimensions L: 270 mm
W: 200 mm
H: 100mm
Mass 0.94 kg